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Dr. Ralf Kemkemer
Group Leader


As the basic units of life, cells with their internal structures are on one hand in tightly maintained homeostasis but are on the other hand very dynamic and adaptive to external signals. Embedded in their native microenvironment, cells perceive and process signals of physical and chemical nature.
These signals cooperatively regulate the cells’ function and integrity. Although a detailed knowledge of the interactions between cells and their surroundings is of fundamental importance in biology, medicine or applied technologies many elementary mechanisms are not fully understood. To elucidate such mechanisms and to explore their capability in applied fields, we make use of novel materials, micro-fabrication techniques, mechanical manipulations methods, and light microscopy.


ZWE Biomaterialien
http://www.mf.mpg.de/biomaterialien


linkPfeil Force induces reorganization of the cytoskelton

We try to obtain a profound understanding of molecular and biophysical processes in force-induced cellular responses (see e.g. Biophysical Journal, 95, 3470-78, 2008). Of special interest is the temporal and spatial dynamics of the cellular acto-myosin system ...
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linkPfeil Mechano-sensitivity of senescent cells

With aging, cells alter their internal structures and their ability to keep homeostasis. We suggest that some age-related changes in cells may affect their mechano-transduction pathways. That in turn may influence other functions such as the ability of aged ...
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linkPfeil Cell-type specific biomaterials

We aim to understand the underlying mechanisms of topography and geometry sensing of cells (e.g. ChemPhysChem, 5, 85-92, 2004; Biophys. J, 2006) and explore the suitability of appropriately structured materials for application in cell-type specific tissue ...
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linkPfeil Automated controller systems and multi-cellular phenomena

We are interested in an engineer-like technical approach to understand quantitatively the physical parameters in cell migration and the cellular response to external signals (e.g. Biophys. J. 90: 4701-4711, 2006, PNAS 99, 13783-8, 2002). Moreover, we attempt to ...
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