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| Research Group Garcia-Saez |
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Research Group Garcia
Membrane Biophysics
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Our research is focused on the study of dynamic membrane processes from a quantitative point of view. We have a special interest in the mitochondrial membrane alterations during apoptosis and the mechanism of action of the Bcl-2 proteins. To address these problems, we make use of our expertise in membrane biophysics, advanced microscopy and single molecule techniques.
Research Group Leader: Dr. Ana Garcia-Saez
| Heisenbergstr. 3 |
Phone: + 49 711 689-3611 |
| 70569 Stuttgart |
Fax: + 49 711 689-3612 |
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The proteins of the Bcl-2 family are essential regulators of apoptosis. They control a key event in apoptosis:
the permeabilization of the mitochondrial outer membrane (MOM) that leads to the activation of caspases and to cell death.
Because the Bcl-2 proteins have an important role in the formation of tumors and in the cellular responses to anti-cancer
therapies, understanding the molecular details of their action is of great therapeutic interest.
We apply fluorescence correlation spectroscopy, atomic force microscopy and single particle tracking to in vitro reconstituted systems in order to characterize the complex interaction networks between the members of the Bcl-2 proteins.
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Fig.Images obtained in different membrane model systems. From left to right:
supported bilayer, AFM - giant unilamellar vesicle, confocal - cellular bleb, confocal - live cell, confocal. |
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