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Mechanisms of force-induced dynamic cell reorganizations


We try to obtain a profound understanding of molecular and biophysical processes in force-induced cellular responses (see e.g. Biophysical Journal, 95, 3470-78, 2008). Of special interest is the temporal and spatial dynamics of the cellular acto-myosin system and focal adhesion upon application of external forces and at the migration through confined 3D-like environments.
FRET Mirgation_Channel
FRET image of Rho GTPase activity Deformation of pancreas tumor
cells at the migration
though small channels

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das Bild oder den Link.

download Video: Deformation of pancreas tumor cells at the migration though small channels



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